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To accomplish this, the trial was designed to focus on the assessment of objective endpoints such as small nerve fiber quantification by using both skin biopsy and corneal confocal microscopy and to relate these findings to semiobjective sensory testing by using QST, which directly assesses the effects of potential changes in cutaneous innervation

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Simple adjustments can significantly reduce acid reflux symptoms: Avoiding trigger foods like spicy or fatty meals Eating smaller, more frequent meals Not lying down immediately after eating Maintaining a healthy weight Quitting smoking and limiting alcohol intake If symptoms persist despite treatment, or if complications such as difficulty swallowing or weight loss occur, specialized care may be necessary

doi: 10.1016/j.nano.2014.12.003